Introduction to Drug Disposition and Pharmacokinetics

Welcome to the website for Introduction to Drug Disposition and Pharmacokinetics by Stephen H. Curry and Robin Whelpton. This website gives you access to the rich tools and resources available for this text.

This site contains a number of questions, exercises, simulations and more detailed explanations of selected topics which the authors feel readers will find helpful. The authors have taken this approach to encourage learning beyond that which is possible using the book on its own. Thus the site materials will assist you in improving your competence in the simple calculations that are essential to the subject, and also lead you to utilize other literature to broaden the educational experience. Hopefully, it will stimulate thinking, both by the reader on his or her own, and in the group discussions that we have found to be very helpful in the discovery of “grey” areas of the subject, and which can facilitate understanding of controversial issues.

The types of resource include:

• Multiple choice questions: so that readers can quickly check their knowledge and comprehension; these can also be used as discussion topics.
• Calculations: for readers to become proficient in applying the models described in the book.
• Simulations: so that the effects of changing pharmacokinetic parameters may be observed.
• Short questions: requiring brief explanations and sketches.
• Topics for group discussion or private research: these require students to think and research using more advanced texts and original scientific papers, and to reflect generally on what they have learnt.

Answers to the questions and, where appropriate, worked examples are provided, so that individuals using the book as a self-teaching aid can monitor their progress. Course leaders should be able to devise suitable questions for enhancing learning, and for testing their students.

We have suggested initial values for the simulations which have been designed to reinforce the material in the book and should prove useful to all readers . Additionally, curve-fitting using the method of residuals is demonstrated using a spreadsheet which can be used as a template for other sets of data. There is a detailed presentation explaining the relationship between apparent volumes of distribution in multiple-compartment models.

Using the menu at the top, select a resource. This will allow you to access a particular resource section. You will then have the option of selecting resources within the section or going directly to a specific chapter

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